Deltazinone 1

Research use only, not for human use.

Deltazinone 1 (Deltazinone1)is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM.

Deltazinone 1 (Deltazinone1)is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM; displays excellent selectivity against a broad panel of pharmacologically relevant proteins; inhibits the PDEδ-Ras interaction in in-cell measurement with Kd of 58±17 nM, exhibits less unspecific cytotoxicity than Deltarasin in a set of human pancreatic cancer cell lines, including KRas mutation and oncogenic KRas-dependence, decreases Ras-mediated signalling in pancreatic cancer cells.

Deltazinone1

MAPK/ERK Signaling

Ras

Ras

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894554-89-3

457.58

C27H31N5O2

>98% (HPLC)

——

O=C(NCC(C1=CC=CC=C1)C)CCCN2N=C(C)C3=C(C)N(C4=CC=C(C)C=C4)N=C3C2=O

4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)-N-(2-phenylpropyl)butanamide

(-20℃)

With Ice Pack

≥ 2 years